Cook ground beef.
Cook noodles.
Mix spaghetti sauce, pepperonis, ground beef, and noodles.
Transfer to oven safe dish (9x13).
Cut cream cheese into cubes and put onto casserole and press some down into it and leave some on top
Sprinkle mozzarella and cheddar cheese on top.
Bake at 350 until cheese is melted and casserole heated. (About 20 minutes)
Serve with or without mixing cream cheese into casserole.